Probiotics for Diverticulitis: A Comprehensive Guide to Gut Health

Probiotics for diverticulitis have gained significant attention in recent years as a potential complementary treatment for this painful and often recurrent condition. Diverticulitis is a digestive disorder characterized by the inflammation or infection of small pouches called diverticula that develop along the walls of the colon. While the exact cause of diverticulitis remains unclear, research suggests that an imbalance in the gut microbiome may play a role in the development and progression of this condition (1).

The Gut Microbiome and Diverticulitis

The human gut is home to trillions of microorganisms, including bacteria, fungi, and viruses, collectively known as the gut microbiome. A healthy gut microbiome is essential for maintaining optimal digestive function, immune health, and overall well-being. However, various factors, such as poor diet, stress, and antibiotic use, can disrupt the delicate balance of the gut microbiome, leading to a state of dysbiosis (2).

Recent studies have found that individuals with diverticulitis often exhibit dysbiosis, characterized by a decrease in beneficial bacteria such as Bifidobacteria and Lactobacilli and an increase in potentially harmful bacteria (3). This imbalance in the gut microbiome may contribute to the inflammation and infection associated with diverticulitis (4).

How Probiotics Can Help with Diverticulitis

Probiotics are live microorganisms that, when consumed in adequate amounts, confer health benefits to the host. These beneficial bacteria can help restore balance to the gut microbiome and may offer several potential benefits for individuals with diverticulitis (5):

Reducing inflammation: Probiotics have been shown to possess anti-inflammatory properties, which may help reduce the inflammation associated with diverticulitis (6).

Strengthening the gut barrier: Certain probiotic strains can help strengthen the intestinal barrier, preventing the translocation of harmful bacteria and toxins from the gut into the bloodstream (7).

Modulating the immune system: Probiotics can interact with the immune cells in the gut, helping to regulate the immune response and reduce the risk of excessive inflammation (8).

Competing with harmful bacteria: Beneficial bacteria in probiotics can compete with potentially harmful bacteria for nutrients and space in the gut, helping to maintain a healthy microbial balance (9).

The Best Probiotic Strains for Diverticulitis

While research on the specific probiotic strains most effective for diverticulitis is still limited, some strains have shown promise in clinical studies:

Lactobacillus casei DG: A randomized, double-blind, placebo-controlled study found that supplementation with Lactobacillus casei DG significantly reduced the recurrence of diverticulitis compared to placebo (10).

Bifidobacterium infantis 35624: In a small pilot study, supplementation with Bifidobacterium infantis 35624 was found to reduce inflammation and improve symptoms in patients with symptomatic uncomplicated diverticular disease (11).

VSL#3: VSL#3 is a high-potency probiotic mixture containing eight different strains of beneficial bacteria. A randomized, double-blind, placebo-controlled study found that VSL#3 supplementation reduced abdominal pain and bloating in patients with symptomatic, uncomplicated diverticular disease (12).

It is important to note that, while these strains have shown promise, more research is needed to fully understand their efficacy in the context of diverticulitis. As always, it is best to consult with a healthcare professional before starting any new supplement regimen.

Lifestyle and Dietary Considerations

In addition to probiotics, lifestyle and dietary modifications can play a significant role in managing diverticulitis and promoting gut health.

High-fiber diet:

Consuming a diet rich in fiber, particularly from fruits, vegetables, and whole grains, can help promote regular bowel movements and reduce the risk of diverticulitis (13).

Hydration:

Staying well-hydrated by drinking plenty of water throughout the day can help keep stools soft and prevent constipation, which may exacerbate diverticulitis symptoms (14).

Regular exercise:

Engaging in regular physical activity can help promote digestive health and reduce the risk of diverticulitis (15).

Stress management:

Chronic stress has been linked to digestive issues and may worsen diverticulitis symptoms. Incorporating stress-reducing techniques such as meditation, yoga, or deep breathing exercises may be beneficial (16).

Conclusion

Probiotics for diverticulitis offer a promising complementary approach to managing this painful and often recurrent condition. By restoring balance to the gut microbiome, probiotics may help reduce inflammation, strengthen the gut barrier, modulate the immune system, and compete with harmful bacteria. While more research is needed to fully understand the specific strains and dosages most effective for diverticulitis, incorporating probiotics alongside lifestyle and dietary modifications may help promote gut health and reduce the risk of recurrence.

As always, it is essential to consult with a healthcare professional before starting any new supplement regimen, especially if you have a pre-existing medical condition or are taking medications. With the guidance of a qualified practitioner and a holistic approach to gut health, probiotics may offer a valuable tool in the management of diverticulitis and the promotion of overall digestive well-being.

References:

Tursi, A., Scarpignato, C., Strate, L. L., Lanas, A., Kruis, W., Lahat, A.,… & Danese, S. (2020). Colonic diverticular disease. Nature Reviews Disease Primers, 6(1), 1–19.

Illiano, P., Brambilla, R., & Parolini, C. (2020). The mutual interplay of gut microbiota, diet, and human disease. The FEBS Journal, 287(5), 833–855.

Barbara, G., Scaioli, E., Barbaro, M. R., Biagi, E., Laghi, L., Cremon, C., … & Festi, D. (2017). Gut microbiota, metabolome, and immune signatures in patients with uncomplicated diverticular disease. Gut, 66(7), 1252–1261.

Tursi, A., Mastromarino, P., Capobianco, D., Elisei, W., Miccheli, A., Capuani, G., & Brandimarte, G. (2016). Assessment of the fecal microbiota and fecal metabolome in symptomatic, uncomplicated diverticular disease of the colon. Journal of Clinical Gastroenterology, 50, S9-S12.

Ticinesi, A., Nouvenne, A., Corrente, V., Tana, C., Di Mario, F., & Meschi, T. (2019). Diverticular disease: a gut microbiota perspective. Journal of Gastrointestinal and Liver Diseases, 28(3), 327–337.

Ng, S. C., Lam, E. F., Lam, T. T., Chan, Y., Law, W., Tse, P. C., … & Wu, J. C. (2013). Effect of probiotic bacteria on the intestinal microbiota in irritable bowel syndrome. Journal of Gastroenterology and Hepatology, 28(10), 1624–1631.

Sindhu, K. N. C., Sowmyanarayanan, T. V., Paul, A., Babji, S., Ajjampur, S. S. R., Priyadarshini, S., … & Kang, G. (2014). Immune response and intestinal permeability in children with acute gastroenteritis treated with Lactobacillus rhamnosus GG: a randomized, double-blind, placebo-controlled trial. Clinical Infectious Diseases, 58(8), 1107–1115.

Yan, F., & Polk, D. B. (2011). Probiotics and immune health. Current Opinion in Gastroenterology, 27(6), 496–501.

Collado, M. C., Meriluoto, J., & Salminen, S. (2007). Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Letters in Applied Microbiology, 45(4), 454–460.

Tursi, A., Brandimarte, G., Elisei, W., Picchio, M., Forti, G., Pianese, G., … & Danese, S. (2013). Randomised clinical trial: mesalazine and/or probiotics in maintaining remission of symptomatic uncomplicated diverticular disease–a double-blind, randomized, placebo-controlled study. Alimentary Pharmacology & Therapeutics, 38(7), 741–751.

Quigley, E. M. (2012). Prebiotics and probiotics: their role in the management of gastrointestinal disorders in adults. Nutrition in Clinical Practice, 27(2), 195–200.

Lahner, E., Esposito, G., Zullo, A., Hassan, C., Cannaviello, C., Paolo, M. C. D., … & Annibale, B. (2012). High-fiber diet and Lactobacillus paracasei B21060 in symptomatic, uncomplicated diverticular disease. World Journal of Gastroenterology: WJG, 18(41), 5918.

Böhm, S. K. (2015). Risk factors for diverticulosis, diverticulitis, diverticular perforation, and bleeding: a plea for more subtle history taking. Viszeralmedizin, 31(2), 84–94.

Eglash, A., & Lane, C. H. (2006). What is the most beneficial diet for patients with diverticulosis?. The Journal of Family Practice, 55(9), 813–815.

Strate, L. L., Liu, Y. L., Aldoori, W. H., Syngal, S., & Giovannucci, E. L. (2009). Obesity increases the risk of diverticulitis and diverticular bleeding. Gastroenterology, 136(1), 115–122.

Spiller, R., & Lam, C. (2012). An update on post-infectious irritable bowel syndrome: role of genetics, immune activation, serotonin, and altered microbiome. Journal of Neurogastroenterology and Motility, 18(3), 258.